Generic name: compound paracetamol and amantadine capsules
Trade name: crack
English name:
Chinese Pinyin: Compound Paracetamol Wan 'an Capsule
Drug category: antipyretic and analgesic drugs and non-steroidal anti-inflammatory and analgesic drugs.
Each capsule contains acetaminophen 250 mg, amantadine hydrochloride 100 mg, chlorphenamine maleate 2 mg, artificial bezoar 10 mg and caffeine 15 mg.
Properties This product is a capsule with light yellow granules.
Pharmacology and Toxicology This product is a compound antipyretic and analgesic drug, in which acetaminophen has antipyretic and analgesic effects, amantadine has anti-influenza A virus effect, and the rest components have antipyretic, analgesic, anti-inflammatory and anti-allergic effects.
counteraction
(1) Occasional rash, nausea, vomiting, sweating, abdominal pain, anorexia and pallor. Some patients have drowsiness or mild dizziness after taking the medicine for the first time, and the symptoms disappear after stopping taking the medicine. (2) Cyanosis is occasionally caused by methemoglobinemia. Long-term or large-scale use is harmful to liver and kidney function. (3) Sometimes it can cause hallucinations and mental disorders, and occasionally there are vague language and involuntary eye movements, which are generally manifestations of overexcitation or central nervous system poisoning. (4) For elderly patients, it can cause dysuria and syncope, often causing postural hypotension. (5) Occasionally leukopenia. (6) Refractory adverse reactions include: inattention, dizziness, excitability, anorexia, nervousness, purple reticular spots or reticular green spots on the skin, sleep disorder, nightmares, etc. Rare headache, blurred vision, dry mouth and nose, constipation, fatigue and weakness. (7) The swelling of lower limbs can be seen after long-term treatment.
taboo
Those who are allergic to the ingredients of this product and patients with active peptic ulcer are prohibited.
Matters needing attention
(1) Avoid driving and aerial work after taking this product.
(2) Drinking alcohol while taking this product will increase the adverse reactions of this product.
(3) Use with caution in the following situations.
① Patients with hepatic and renal insufficiency.
② History of cerebrovascular disease, recurrent eczema-like rash, peripheral edema, congestive heart failure, psychosis or severe neurosis, epilepsy.
(4) Cross-allergic reaction For a few patients who are allergic to aspirin and have asthma, mild bronchospasm reaction may occur after taking it.
(5) It is not advisable to use drugs in large quantities or for a long time to prevent damage to hematopoietic system and liver and kidney functions.
(6) Interference with laboratory inspection. Using glucose oxidase/peroxidase method to measure blood sugar will get false low value; The false high value can be obtained by measuring serum uric acid with phosphotungstic acid method. The qualitative screening test of 5- hydroxyindoleacetic acid in urine with nitroso-catechol reagent can get false positive results without affecting quantification. Large dose application or long-term application of small dose can increase prothrombin time, serum bilirubin, serum lactate dehydrogenase and serum transaminase.
Medication for pregnant and lactating women
Amantadine, acetaminophen and artificial bezoar in this product can pass through the placenta, which may have adverse effects on the fetus, toxic to the embryo and teratogenic; Except artificial bezoar, which can be secreted by milk, it is forbidden for pregnant women and lactating women.
Children's medication
Not recommended.
Medication for elderly patients
Due to liver and renal insufficiency, it should be used with caution.
drug interaction
(1) Long-term and large-scale application of this product can reduce the synthesis of coagulation factors in the liver, so it can enhance the anticoagulant effect.
(2) When combined with barbiturates and other liver drug enzyme inducers, it can increase the toxic reaction to the liver.
(3) Combination with chloramphenicol can prolong the half-life of chloramphenicol and increase its toxicity.
(4) Combined with other anti-tremor drugs, anticholinergic drugs, antihistamines, phenothiazines or tricyclic antidepressants, atropine-like side effects can be enhanced, especially for patients with mental disorders, hallucinations and nightmares, and the dosage of these drugs needs to be adjusted.
(5) The central nervous system stimulant can enhance the excitability of the central nervous system when combined with this product, and in severe cases, it can cause adverse reactions such as convulsion or arrhythmia.
excessive
Excessive use should closely observe the occurrence of side effects and poisoning, and pay attention to monitoring blood pressure, pulse, breathing and body temperature. If you take more than 8 tablets, you will have symptoms such as nausea, vomiting, stomachache or stomach cramp, diarrhea, anorexia and hyperhidrosis. Will appear soon and last for 24 hours. Liver function damage occurred within 2 ~ 4 days, manifested as pain in liver area, hepatomegaly and jaundice. In case of overdose, gastric lavage, vomiting, and massive rehydration and diuresis, urine acidification should be done immediately to increase drug excretion, and acetaminophen antagonist acetylcysteine should be given, but activated carbon should not be given, because it may affect the absorption of antidote; Acetylcysteine 140mg/kg for the first time, then 70mg/kg, every 4 hours 1 time, *** 17 times; When the condition is serious, it can be injected intravenously. Antagonists should be used as soon as possible. /kloc-the curative effect is satisfactory within 0/2 hours, but poor after 24 hours. At the same time, other symptomatic and supportive therapies should be given. And observe whether there is excessive exercise, convulsion, arrhythmia and hypotension, and give sedatives, anticonvulsants and antiarrhythmic drugs as needed. In order to control the symptoms of central nervous system poisoning, physostigmine can be injected slowly intravenously.