Cold is the most common acute upper respiratory tract infection in clinic, mainly caused by virus infection, rhinovirus is the most common pathogen, others include coronavirus, respiratory syncytial virus, parainfluenza virus, etc. Cold usually occurs at the turn of seasons, usually with an acute onset. In the early stage, sneezing, stuffy nose, itchy nose and runny nose are the main symptoms, and cough, expectoration and sore throat may occur 2-3 days later.

A cold is a self-limited disease, which usually heals itself in 5-7 days, and there is no specific antiviral drug. The treatment of a cold mainly focuses on symptomatic treatment and relieving cold symptoms, such as limb pain, headache, fever and other symptoms. You can use acetaminophen or ibuprofen to relieve symptoms, and you can use chlorpheniramine or diphenhydramine to relieve symptoms. You can use dextromethorphan, ambroxol, myrtle oil and other antitussive and expectorant drugs to relieve symptoms. In addition, patients with colds should drink more water, eat lightly, pay attention to rest and maintain oral hygiene.

amoxicillin is a kind of synthetic penicillin antibacterial drug, which mainly inhibits the synthesis of bacterial cell wall, so that water continuously permeates into the bacteria, causing the bacteria to expand and rupture and die. It has the advantages of rapid sterilization, wide antibacterial spectrum, high oral bioavailability, wide tissue distribution, good permeability and few adverse reactions. It is mainly used to treat respiratory infection, urogenital infection, skin and soft tissue infection, gonorrhea, syphilis, typhoid fever and other bacteria in clinic. In addition, amoxicillin can also be combined with clarithromycin, metronidazole or tetracycline to eradicate Helicobacter pylori.

Azithromycin belongs to macrolide antibiotics in 15 yuan, which plays an antibacterial role mainly by inhibiting the synthesis of bacterial protein. It is mainly used to treat acute pharyngitis, laryngitis, tonsillitis, otitis media, sinusitis and other upper respiratory tract infections, acute bronchitis, pneumonia and other lower respiratory tract infections, urogenital system infections and skin and soft tissue infections. Compared with erythromycin, roxithromycin, clarithromycin and other similar drugs, azithromycin has the advantages of wide tissue distribution, high tissue concentration, long half-life, targeted sterilization, long action time and high medication compliance, and is the first choice for the treatment of mycoplasma infection in clinic.

The cause of cold is virus infection. Amoxicillin and Azithromycin are both antibacterial drugs, which are ineffective for virus infection. Antibiotics can't be used only for one symptom of "sore throat". However, patients with cold usually have reduced local immune function of respiratory tract, and bacteria in oral cavity can easily invade respiratory tract, thus causing secondary bacterial infections of respiratory tract, such as acute pharyngitis, sinusitis, otitis media and even pneumonia. At this time, the patient may show fever and chills, cough with yellow pus and phlegm, purulent throat, elevated white blood cells, etc., and should seek medical attention in time. After the diagnosis, he can take antibacterial drugs such as amoxicillin or azithromycin under the guidance of a doctor, and amoxicillin is the first choice. If the symptoms do not improve after using amoxicillin, accompanied by paroxysmal irritating cough, and it is found that dermatitis, diarrhea, earache and other manifestations outside the lung may be mycoplasma infection, you can take azithromycin empirically under the guidance of a doctor.