Synonym Phoenix Egg (《植物名实图考》). The source is the seeds of the plant thujaplicin of the family Thujaplicaceae. Chemical composition of the globular fruit (including seeds) containing hematite glucoside 0.086% (seeds of the content of about 0.2 ~ 0.3%), the new hematite glucoside A, B, C, D, E, F, G, a large number of free palmitic acid (the outer testa contains 6.95%), a large amount of starch, and also contains β-carotene, cryptoxanthin, corn flavin, and other pigments. Usage and dosage for internal use: decoction, 3-5 money; or powder. Externally: Ground into powder and applied. Adverse Reactions and Treatments "Southern Main Poisonous Plants": Sutherlandia, the seeds and the heart at the top of the stem are poisonous. Poisoning symptoms: dizziness, vomiting. Antidote: Gastric lavage with 1:1000-1:5000 potassium permanganate solution or 0.5-4% ellagic acid solution. Before all the poison is vomited out, fingers or chicken feathers can be used to stimulate the throat to induce vomiting. Pharmacological effects ① Carcinogenic effect, since 1962, found to be mixed in food feeding rats can produce liver, kidney and other tumors, has been synthesized as a carcinogen hematoxylin. It is generally believed that it is similar to dimethylnitrosamine, can be metabolized into diazomethane in the body and a variety of cells have carcinogenic effects. Sulforaphanin must be in the intestine by the enzyme or bacterial decomposition into sulforaphanin, only after the role; sulforaphanin must be taken orally can cause cancer, injection is not (newborn rats in the subcutaneous tissue also contains decomposition of the enzyme, at this time, subcutaneous injection, can also be carcinogenic, 3 ~ 4 weeks after birth, this enzyme is gone). Sulforaphanin is effective in both oral and injected form, and a single injection is sufficient to produce tumors in most of the rats. Kidney tumors are likely to occur in those fed for a shorter period of time, and liver tumors are likely to occur in those fed for a longer period of time, while tumors of the colon are less likely to occur, and it has nothing to do with the time of feeding. Young immature rats were prone to develop renal true tumors, renal sarcomas, and renal mesenchymal tumors, while renal adenomas were not related to the degree of maturity. Tumors were always produced after 6 months of suetoside administration (even in intrauterine exposure, tumors were not seen until after 6 months). The carcinogenicity rate of hematoxylin to rats was 100%, while that of hematoxylin was 85%, which was not related to the species of rats. In addition to rats, mice, guinea pigs, gold voles, etc. can also be carcinogenic. Sulforaphane can produce various tumors caused by sulforaphane, such as intraperitoneal injection can also produce duodenal tumors. Caused by the tumor can be transplanted. Rat kidney adenomas morphologically similar to human or other animals, is caused by direct action on the renal tubular epithelial cells. ② Neurotoxicity cattle eat ironwood fruit seeds, can cause paralysis, and often amyotrophic lateral sclerosis of the spinal cord; thin bundles and dorsal fasciculus of the spinal cerebellum to produce myelin sheath loss, and osmiophilic substances deposited. In the central nervous system of rats, no abnormal lesions were found. If the rat or golden vole fetus in the mother's body is exposed to hematoxylin, can cause obvious postnatal malformations of the central nervous system, preventing its normal development (mainly the two hemispheres of the brain) and the formation of "microcephaly", bony cranial roof narrowing, but the survival time is still quite long; some rats in the 13 ~ 15 months, there are gliomas. The principle of toxic effect has not been fully elucidated. The most striking and early lesions in rats are in the liver. The degree of lesions is related to the dose, light loss of cytoplasmic basophilic and glycogen, while glucose-6-phosphatase decreased; heavy extensive central lobule hemorrhage, necrosis, hepatic ribonucleic acid, total phospholipids decreased, protein synthesis of the liver is also decreased, in the liver of the mouse, so that the H3-dioxopyrimidine riboside into the RNA and the C14-thymidine riboside into the DNA was inhibited. Protein synthesis was not affected in kidney, spleen and small intestine. Sulforaphanin and its glycosides are "alkylating" in vivo and in vitro. In Drosophila and S. typhimurium tests, it was also found that siderosides are potent mutation inducers. Subcutaneous injection of sultamicoside into mice with Ehrlich ascites carcinoma had antitumor effects similar to those of mitomycin C and oxytetracycline. Sulforaphane has minimal toxicity to cold-blooded animals. Orally administered to mice, no immediate toxicity phenomenon, need to be 12 to 18 hours, before respiratory distress, and finally paralyzed and died. The oral LD50 for mice is 1.67 mg/g. The oral LD50 for mice is 1.67 mg/g. The oral LD50 for facultative rats is 1.0 g/kg. Animal autopsy after death, the lesion is mainly depressed blood, hemorrhage. Sulforaphane glycosides on respiration, blood pressure, heart, blood vessels, intestines or uterus effect is slight. Bitter and astringent flavor, flat. Toxic. ① "Modern Practical Chinese Medicine": "Bitter, flat, sour and astringent, non-toxic." ② Lu Chuan Materia Medica: "Light in flavor, cold in nature." Functions and Indications ① "Modern Practical Chinese Medicine": "An astringent, emmenagogue, digestive aid, suppressing cough and expectorant. Starch in the fruit, cure dysentery and eructation." ② Lu Chuan Materia Medica: "Anti-inflammatory, stops bleeding. Cure phlegm and cough, dysentery, cuts and bruises."