The outpatient clinic often encountered young girls, the body is already very slim, but still want to lose weight, to our doctor to consult the metformin to eat how to lose weight?

At first, we were surprised that this drug can be used in this way. Then we studied, it turned out that most of the diabetic patients and doctors are familiar with metformin, in addition to lowering blood sugar really have some unexpected effects, and even online as a miracle drug. Then today to talk about this "miracle drug" metformin.

With artemisinin from Artemisia annua, metformin also comes from a plant - goat bean (Galega officinalis). This is a perennial herb of the legume family native to southern Europe and western Asia. It has a wide range of medicinal uses.

Diabetes was a terminal disease with no cure before the invention of insulin, and in 1922 a low-toxicity guanidine alkaloid, goat's-bean, was found. Scientists then found a series of guanidine derivatives. The French diabetologist Jean Sterne, who is credited with the discovery of the effects of metformin, conducted the first human study of metformin and named it "Glucophage" (glucose eater), and in 1929 metformin was born.

But metformin was a bit of an anachronism, and in 1922 the scientist Banting discovered insulin. Insulin was a superstar of its time, emitting a brilliant light that completely overshadowed metformin. Almost all doctors thought: diabetes has been completely conquered. But with the clinical use of insulin, there were many adverse effects, and type 2 diabetes is predominantly insulin-resistant, so there was a need for more and better antidiabetic drugs, and another boom in the development of hypoglycemic drugs was set off. That's how the biguanide family came back into focus.

In the middle of the last century, metformin was marketed in France, phenelzine was marketed in the United States, and butorphanol was marketed in Germany.

In 1957, with the introduction of metformin into clinical use, a new chapter in the history of the fight against diabetes was opened.

(Metformin was first used in the clinical treatment of diabetes by Prof. Jean Sterne (1909-1997) in France)

All stories have their twists and turns, and for metformin there were ups and downs, with the results of a study in 1968 suggesting an increased risk of lactic acidosis with phenelzine. Thus, in the late 1970s, phenelzine and butylguanidine were almost completely withdrawn from the market, and it was inevitable that metformin, which is from the same root, was recommended to be withdrawn from the market, and once again fell into a situation of being left out in the cold.

However, subsequent international studies and clinical applications in China over the past 30 years have shown that metformin, because of its different molecular structure, does not inhibit the release and oxidation of lactic acid, and the incidence of lactic acidosis is much lower than that of its two brothers, making it a very safe drug.

Metformin was approved by the FDA in 1995. It has been used until now, and a large number of studies have confirmed that metformin is the first-line drug in the treatment of type 2 diabetes mellitus, preventing diabetes-induced macrovascular and microvascular lesions, reducing insulin resistance, improving lipid metabolism, and reversing pre-diabetes.

It can be said that metformin is a major contributor in the field of diabetes treatment.

Regarding Metformin, we have to start with its main features, which happen to be archived in the instruction manual.

Indications

1. Metformin tablets are preferred for use in type 2 diabetes mellitus that is ineffective in the treatment of simple dietary control and physical exercise, especially obese type 2 diabetes.

2. This product is used in combination with insulin to reduce insulin dosage and prevent hypoglycemia.

3. It can be used in combination with sulfonylurea hypoglycemic drugs with synergistic effect.

Adverse effects

1. Occasionally nausea, vomiting, diarrhea, abdominal pain, abdominal distension, dyspepsia, malaise.

2. Occasionally fatigue, weight loss, headache, dizziness, abnormal taste, rash, chills, flu-like symptoms, palpitations, flushing.

3. Rarely lactic acidosis, manifested by vomiting, abdominal pain, hyperventilation, and impaired consciousness.

Contraindications

Hypersensitivity to the product, diabetic ketoacidosis, hepatic and renal insufficiency (serum creatinine more than 1.5 mg/dl), pulmonary insufficiency, cardiac failure, acute myocardial infarction, severe infections and traumatic injuries, major surgeries, as well as clinically hypotensive and hypoxic conditions, alcoholism, vitamin B12, folic acid It is also contraindicated in patients with alcoholism, vitamin B12, folic acid deficiency, severe diabetic nephropathy, diabetic fundopathy, and pregnant and lactating women.

You can focus on the adverse reactions: nausea, diarrhea, weight loss. Many people see that there is this effect, and regardless of whether it is an adverse reaction, they judge that eating metformin can lose weight.

With the depth of the study metformin also has numerous glucose-lowering outside the efficacy, as well as reduce insulin resistance, reduce the role of insulin concentration, can be the treatment of polycystic ovary syndrome, non-alcoholic fatty liver disease, pseudo acanthosis nigricans, to promote the height of the adolescents to increase, to reduce the risk of diabetic patients with tumors, but also anti-aging and Alzheimer's disease.

Additionally there are other highlights:

1. Regulation of intestinal flora

2. Cardiovascular protection

3. Lowering of BMI in prepubertal obese children.

4. Anti-tumor effects

5. Anti-infective effects

6. Preventing the progression of abdominal aortic aneurysms

7. Prolonging lifespan