Long-term application of probiotics is easy to interfere with the establishment of his own probiotic system, and long-term application of probiotics is also easy to form dependence. In addition, long-term use of probiotics sometimes produces drug resistance, so it is not recommended to abuse probiotics. The more probiotics, the worse. Excessive intake or supplementation of probiotics can not only have a positive effect on the human body, but also may increase the burden on human organs, have a negative effect and disturb the normal intestinal environment.