Supplement upstairs. All drugs that can effectively control blood pressure and are suitable for long-term treatment are reasonable choices, including not causing obvious side effects and not affecting the quality of life. Among the six main antihypertensive drugs mentioned upstairs. 1. Patients with heart failure should choose ACE inhibitors and diuretics. 2. The elderly with systolic hypertension should choose diuretics and long-acting dihydropyridine calcium channel blockers. 3. ACE inhibitors can be used for patients with diabetes, proteinuria or mild or moderate renal insufficiency (non-renal vascular). 4. Patients after myocardial infarction can choose β -blockers or ACE inhibitors (especially those with systolic dysfunction) without intrinsic sympathetic action. For patients with stable angina pectoris, calcium channel blockers can also be selected. 5. For patients with abnormal lipid metabolism, α 1 receptor blockers can be used, but β-receptor blockers and diuretics should not be used. 6. With pregnancy, ACE inhibitors and angiotensin II receptor blockers should not be used, and methyldopa can be used instead. 7. Beta blockers should not be used for patients with bronchial asthma, depression and diabetes; Patients with gout should not use diuretics; Beta blockers and non-dihydropyridine calcium channel blockers should not be used in patients with cardiac pacing conduction disorder. Once the diagnosis of essential hypertension is established, lifelong treatment (including non-drug treatment) is usually needed. After treatment with antihypertensive drugs, blood pressure can be controlled satisfactorily, and the dosage of antihypertensive drugs can be gradually reduced, but generally long-term medication is still needed, and hypertension will still recur after stopping treatment. In addition, drug withdrawal syndrome may occur when long-term drug users suddenly stop taking drugs, that is, blood pressure rises rapidly and sympathetic nerve activity increases, such as palpitation, irritability, hyperhidrosis, tachycardia, etc. Patients with coronary heart disease may have myocardial ischemic attack and severe arrhythmia. 1. For patients with mild and moderate hypertension, it is advisable to start with a small dose or a general dose. After 2-3 weeks, if the blood pressure is not satisfactorily controlled, the dosage can be increased or other drugs can be used. If necessary, two or more drugs can be combined for treatment. The better combined medication methods are: ① diuretics and beta blockers, ② diuretics and ACE inhibitors or angiotensin II blockers, ③ calcium channel blockers (dihydropyridines) and beta blockers, ④ calcium channel blockers and ACE inhibitors, and ⑤ α and β blockers. Combined medication can reduce the dosage of each drug, reduce the side effects and enhance the antihypertensive effect. 2. It is required to steadily reduce blood pressure during the day and night, and it can be monitored by ambulatory blood pressure method. 3. As far as possible, use a long-acting preparation of 1 tablet daily, which is convenient for long-term treatment and can reduce blood pressure fluctuation.