Please refer to the instructions for paracetamol and cimetidine and do not use them indiscriminately.
Generic name Cimetidine
Alias Mecamylamine; Tai Gumi; Cimetidine
CharacteristicsWhite or off-white crystalline powder; almost odorless, bitter taste. Soluble in methanol, soluble in ethanol, slightly soluble in isopropanol, slightly soluble in water, soluble in dilute hydrochloric acid.
Pharmacological action as an H2 receptor antagonist, can significantly inhibit gastric acid secretion induced by food, histamine or pentagastrin stimulation, and make it less acidic. It has preventive and protective effects on corrosive gastritis caused by chemical stimulation, and also has obvious curative effects on stress ulcers and upper gastrointestinal bleeding. This product has anti-androgenic effect, which is valuable in the treatment of hirsutism. It can attenuate the activity of immunosuppressive cells and enhance the immune response, thus blocking tumor metastasis and prolonging the survival period.
IndicationsThis product is suitable for duodenal ulcer, gastric ulcer, reflux esophagitis, upper respiratory tract hemorrhage, etc.; Veterinary medicine can be applied to the prevention and treatment of chicken gastric erosions, inflammation of adenogastric gland and the immune-enhancing effect on the vaccine of chicken Newcastle disease and the immune-enhancing effect on the vaccine of Marek's disease.
Dosage and administration Oral: At the beginning, 1.2~1.6g per day, divided into 4 times. After the reduction of symptoms (about 10 days), each time to take 0.2g, 3 times a day to maintain, can be taken for several months. After stopping the drug, if the symptoms recur, the drug is still effective. Static injection: 200mg, diluted with saline and slowly injected, 4-6h once, should not exceed 2g / d. The course of treatment are 4-6 weeks.
Precautions 1.Digestive system reactions: the more common are diarrhea, abdominal distension, bitter mouth, dry mouth, mild elevation of aminotransferases, etc. Occasionally, there are severe hepatitis, hepatic necrosis, hepatic steatosis. Abrupt discontinuation of the drug can cause chronic peptic ulcer perforation, which is estimated to be caused by rebound hyperacidity after discontinuation. Therefore, it is necessary to continue to take the drug (400mg per night) for 3 months after completing the treatment. Patients with acute pancreatitis, pregnant and lactating women should not apply. 2. Urinary system reaction: in recent years, there are many reports of acute interstitial nephritis caused by this product, resulting in renal failure. However, this toxic reaction is reversible, and renal function can be normalized after stopping the drug. In order to avoid nephrotoxicity, attention should be paid to checking renal function during the use of the drug. 3. Hematopoietic reactions: the product has a certain inhibitory effect on the bone marrow, a small number of patients can occur reversible moderate granulocytopenia, thrombocytopenia and autoimmune hemolytic anemia, the incidence of which is 0.02% of the drug users. It has also been reported to cause aplastic anemia. Attention should be paid to check the blood picture during the use of the drug. 4. Central nervous system reaction: this product can pass the blood-brain barrier, with a certain degree of neurotoxicity, the more common are dizziness, headache, fatigue, drowsiness and other symptoms. A small number of patients may experience restlessness, dullness of sensation, slurred speech, sweating, localized convulsions or epileptic-like seizures, as well as hallucinations, delusions and other symptoms. 5. Cardiovascular system reaction: there may be bradycardia, facial flushing and so on. When injected intravenously, there are occasional sudden drop in blood pressure, atrial premature beats, cardiac and respiratory arrest. 6. Effects on endocrine and skin: due to the anti-androgenic effect, a large dose of the drug (more than 1.6g per day) can cause gynecomastia, female breast milk, libido, impotence, sperm count reduction, etc., which can be disappeared after stopping the drug. It can inhibit sebum secretion and induce exfoliative dermatitis, dry skin, sebum deficiency dermatitis, alopecia, oral ulcers. Rash, giant urticaria, drug fever, etc. also occur from time to time. 7. Aluminum hydroxide, magnesium oxide or metoclopramide (Gastrofen) can reduce the blood concentration of this product when taken together with this product. 8. Since aluminum sulfate needs to be hydrolyzed by gastric acid to be effective, and this product is to inhibit gastric acid secretion, the combination of the two may reduce the efficacy of aluminum sulfate. 9. Combining with benzodiazepines (Valium, Nitrovalium, Flunitrazepam, Librium) may increase the blood concentration of Valium, aggravate the symptoms of sedation and other central nervous system inhibition, and may lead to respiratory and circulatory failure. When the combination must be used, it can be changed to hydroxyvalium or clonazepam, and the elimination of the latter two is not affected by this product. 10. When patients take digoxin and quinidine at the same time, it is not suitable to use this product. Because this product can inhibit the metabolism of quinidine, and the latter can displace digoxin from its binding site, resulting in an increase in the blood concentration of both quinidine and digoxin. Blood levels should be monitored. 11. This product can delay the metabolism of caffeine, so when used in combination with it, it can enhance the latter's effect and is prone to toxic reactions. Caffeine is contraindicated in patients with gastric ulcer, and caffeine and caffeine-containing beverages should be contraindicated when taking this product. 12. Combined with warfarin anticoagulants, it can reduce the rate of the latter's excretion from the body and lead to bleeding tendency. 13. Due to the increase in pH of gastric juice, when combined with tetracycline, the dissolution rate of tetracycline can be reduced, absorption is reduced, and the effect is weakened (but the enzyme inhibition of this product may increase the blood concentration of tetracycline); if combined with acetylsalicylic acid, the opposite result occurs, and acetylsalicylic acid can enhance the effect. 14. Combining with ketoconazole can interfere with the absorption of the latter and reduce its antifungal activity, but the above changes can be avoided by taking some acidic beverages together. 15. Combining this product with captopril may cause psychotic symptoms. 16. Since this product has a myoneural blocking effect similar to that of aminoglycosides, this effect is not counteracted by neostigmine but only by calcium chloride. Therefore, when combined with aminoglycoside antibiotics, it may cause respiratory depression or respiratory arrest.
Trade Name Paracetamol Tablets
Generic Name Chlorpheniramine Maleate Tablets
Chinese Name Chlorpheniramine Maleate Tablets
Effects and Indications This product is suitable for skin allergies: urticaria, eczema, dermatitis, drug rashes, pruritis, neurodermatitis, insect bites, solar dermatitis. It can also be used for allergic rhinitis, drug and food allergies.
Pharmacological effects As a histamine H1 receptor antagonist, this product can antagonize the capillary dilatation caused by allergic reactions (histamine), reduce the permeability of capillaries, alleviate the wheezing caused by the contraction of the bronchial smooth muscle, this product is more persistent anti-histamine effect, but also has a significant central inhibition, can increase the effect of anesthesia, analgesic, hypnotic and local anesthesia drugs. This product is mainly metabolized in the liver.
Drug interactions 1.Combined with antipyretic and analgesic drugs, it can enhance their analgesic and relief of cold symptoms.2.Combined with central sedative drugs, hypnotics, tranquilizers or ethanol, it can increase the depressant effect on the central nervous system.3.This product can enhance the effect of antidepressants.4.If you are taking other medicines, consult a physician or a pharmacist before using this product.5.
Adverse Reactions The main adverse reactions are drowsiness, thirst, polyuria, sore throat, drowsiness, feeling of weakness, palpitations, skin ecchymosis, bleeding tendency.
Contraindications 1. It is forbidden for those who are allergic to this product. 2. It is forbidden for those who work at high altitude, vehicle drivers, and machine operators during working hours. 3. It is forbidden to take it when the properties of the medicine have changed.
Product specification 4 mg
Dosage Oral Adults 1 tablet each time, 1-3 times a day; children's dosage please consult a physician or pharmacist.
Storage Methods Keep under cover from light and sealed.
Precautions 1.Allergic to the product is prohibited. 2.The elderly are more sensitive should be appropriately reduced. 3.Newborns, pregnant women, lactating women, bladder neck obstruction, pyloroduodenal obstruction, hyperthyroidism, high blood pressure and prostate hypertrophy people with caution. 4.Workers at height, vehicle drivers, machinery operators are prohibited during working hours. 5.Prohibit the use of the drug when the drug has been changed. 6.If you are taking the drug, please consult your physician. 7.If you are taking the drug, please consult your physician. 8. If overdose, or serious adverse reactions, please seek medical attention immediately.7. Children must be used under adult supervision.8. Keep this medicine out of the reach of children.