Generally, if transaminase rises, it means that there is some organ damage, so it is necessary to clarify the cause of the damage and then give corresponding treatment.
Aspartateaminotransferase (AST) exists in various tissues of human body, with the most abundant content in myocardium, followed by liver. In the liver, the absolute value of aspartate aminotransferase (AST) exceeds that of glutamate aminotransferase (ALT).
AST can be divided into two isoenzymes according to its location in cells, namely cytoplasmic aspartate aminotransferase (s-AST) and mitochondrial aspartate aminotransferase (m-AST). Because m-AST is located in mitochondria, it is not easy to release into blood. When the hepatocyte is necrotic, m-AST is released from mitochondria, which makes the serum AST increase. The determination of isoenzymes is helpful to understand the damage degree of myocardium, liver and kidney.
Extended data:
The determination of serum aspartate aminotransferase is helpful to determine whether there is necrosis and injury degree of heart and liver cells. AST increase: it is common in acute and chronic severe hepatitis, cirrhosis, myocarditis, myocardial infarction, nephritis, cholangitis, dermatomyositis, pancreatitis and other diseases.
Because the content of AST in myocardium is the highest, followed by liver, the enzyme activity in blood can increase rapidly after heart and liver cell injury. However, only measuring the total AST activity can not fully reflect the degree of heart and liver injury and judge the prognosis. Determination of serum m-AST can indirectly understand the severity of ultrastructure damage and mitochondrial damage of hepatocytes. M-AST can be used not only as an indicator of heart and hepatocyte necrosis, but also as an indicator of dynamic monitoring of heart and liver diseases.
References:
Aspartate aminotransferase Baidu Encyclopedia