(1) Dietary factors. First of all, long-term malnutrition, starvation or long-term consumption of food containing high fat, high cholesterol (such as fatty meat, egg yolk, cream, chocolate, etc.) is an important reason for the formation of fatty liver.
Additionally, it should be emphasized that many patients, once infected with liver disease or other chronic diseases, are in the quiescent period, they are given increased nutrition and high-calorie diets without moderation, or long-term sustained intravenous drip of high glucose, resulting in over-nutrition, which will eventually lead to fatty liver.
(2) Long-term heavy drinking. Under the action of alcohol can also make the liver fat metabolism is impaired, fat cell accumulation, occur "chronic alcoholism fatty liver". Alcohol is the first killer of liver damage, this is because after alcohol enters the body, mainly in the liver for decomposition and metabolism, the toxicity of alcohol on the liver cells so that the liver cells on the breakdown of fatty acids and metabolism of obstacles, resulting in intrahepatic fat deposition caused by fatty liver. The more alcohol you drink, the more serious fatty liver is. Alcohol in the cause of fatty liver at the same time, can also induce liver fibrosis, causing cirrhosis of the liver.
Men drink 80g of 50-degree liquor per day, women drink 50g, for more than 5 years, there is a risk of fatty liver, drinking 40 to 80g of alcohol per day for the risk of hepatic fibrosis and cirrhosis threshold, more than this threshold can make the incidence of hepatic fibrosis and cirrhosis increased significantly.
(3) Obesity. About half of the obese patients can be seen with mild fatty liver, in patients with severe obesity, the incidence of fatty liver can be as high as 60% ~ 90%. Obese patients can be seen to have a clear tendency to fatty liver.
(4) Drugs or chemical poisons. Such as steroid hormones, growth hormone, salicylic acid preparations (such as aspirin), some sedative sleeping pills, industrial or laboratory benzene, arsenic, alcohol, iodoform, carbon tetrachloride, antimony and so on are easy to induce fatty liver. Drug liver damage accounts for 10% of adult hepatitis, fatty liver is a common type. They inhibit the oxidation of fatty acids , cause obstacles to lipoprotein synthesis , reduce the release of lipoproteins from the liver , so that fat accumulates in the liver.
(5) Infection. Such as tuberculosis, chronic ulcerative colitis, chronic bronchitis, chronic liver, gallbladder and kidney disease can often be accompanied by fatty liver.
(6) Endocrine diseases. Diabetes mellitus, anterior pituitary and hyperthyroidism, especially in diabetes mellitus, diabetes mellitus patients due to insulin deficiency , the body's utilization of glucose is reduced in order to replenish energy, the body's free fatty acids increased significantly, these fatty acids can not be fully utilized, so that the liver's fat synthesis hyperactivity, which causes fatty liver. 2 diabetes mellitus patients with the prevalence of fatty liver for 40% ~ 50%, and Most of the patients with type 2 diabetes mellitus have a fatty liver incidence of 40% to 50%, and most of them are above moderate, obesity and chronic alcoholic liver damage are easy to complicate diabetes mellitus, 60% of obese patients with diabetes mellitus, the rate of fatty liver is more than twice as much as that of those who do not have diabetes. Some patients with hepatitis, the liver cells have lesions on triglyceride synthesis and metabolism balance is imbalanced, if eating too much fatty foods, will make the neutral fat accumulation in the liver to form fatty liver.
(7) Chronic hypoxia. Such as severe anemia, cardiovascular and respiratory diseases and high altitude, plateau work, often because of severe hypoxia, affecting the liver's fat metabolism function, thus fatty liver.
(8) Malnutrition. Obese people are prone to fatty liver, clinical often found that some people are very thin but also suffer from fatty liver. This is due to long-term malnutrition, lack of certain proteins and vitamins, causing nutritional deficiency fatty liver. For example, some people suffer from chronic intestinal diseases, long-term anorexia, diet, partiality, vegetarianism, malabsorption syndrome and gastrointestinal bypass surgery, resulting in hypoproteinemia, lack of choline, amino acids or lipotropic substances. At this time, fat mobilization increases, and a large amount of fatty acids are released from adipose tissue into the liver, causing the accumulation of fat in the liver and the formation of fatty liver.
(9) Close relationship with hyperlipidemia. Hypercholesterolemia is closely related to fatty liver, of which high triglyceride is most closely related to fatty liver, the vast majority of which are often accompanied by obesity, diabetes and alcoholism.
(10) Others. People who do not like to exercise and sit for a long time may also have fatty liver.