Yang Jia et al. studied the anti-acute inflammatory effect of the aqueous extract of compound cat's ear herb, and the results showed that it had an inhibitory effect on xylene-induced ear swelling, acetic acid-induced increase in the permeability of abdominal capillaries in mice, as well as on egg white-induced foot and metatarsal swelling in rats.
Wang Aiwu et al. explored the effects of different extracts of Cat's ear herb on tumor cells cultured in vitro, extracted cat's ear herb saponins and polysaccharides by systematic solvent method, and observed the effects of different concentrations of saponins and polysaccharides on sarcoma S180, Ehrlich ascites tumor EAC, and human breast cancer cell line MCF-7 cultured in vitro by employing the MTT and colony-forming assay methods.
The results showed that saponins and polysaccharides had different effects on the growth and colony formation of the three tumor cell lines, and the amount of saponins administered was obviously positively correlated with the tumor suppression rate and colony formation, while polysaccharides had an optimal concentration. Zhou Li et al. found that the ethanol extract of Cat's ear herb had a strong induction of tumor necrosis factor (TNF), and among the 36 herbs screened, Cat's ear herb (70% ethanol extract) induced the strongest TNF effect.