In recent years, people have gradually become familiar with the phenomenon of gradual freezing. Let's take a look at what gradual freezing is. Ordinary people will gradually freeze people. What is the disease of gradually frozen people? The cause of amyotrophic lateral sclerosis is still unknown. 20% of cases may be related to heredity and genetic defects. In addition, some environmental factors, such as aluminum poisoning, may also cause motor neuron damage. At present, the main theories of motor neuron injury are: 1. Accumulation of neurotoxic substances, glutamic acid accumulation between nerve cells, resulting in nerve cell damage over time. 2. Free radicals destroy nerve cell membranes. 3. Without nerve growth factor, nerve cells can't continue to grow and develop. Early symptoms are mild and easily confused with other diseases. Patients may only feel some symptoms, such as weakness, muscle jumping and fatigue, and gradually progress to muscle atrophy and dysphagia. Finally, respiratory failure occurred. According to the clinical symptoms, it can be roughly divided into two types: 1. The symptoms of limb onset are progressive atrophy and weakness of limb muscles, and finally respiratory failure. 2. Difficulty in swallowing and speaking appeared in the early stage of medulla oblongata, which quickly progressed to respiratory failure. Ordinary people also get frostbite. In 20 14, the former baseball player of Boston College in the United States launched ALS Ice Bucket Challenge, requiring participants to post video content of themselves being drenched by ice water online, and then participants can ask others to participate in this activity. ALS is amyotrophic lateral sclerosis (ALS), which is known as the top five terminal diseases in the world. People with ALS are generally called "frozen people". Maybe you haven't experienced the life of a frozen person personally, but you have experienced the numbness of your hands and feet to some extent. The feeling of losing your legs in an instant will make the whole person panic. But their bodies are always in a state of panic, as if they were gradually frozen by ice and snow. Today is the leg, tomorrow is the hand and the day after tomorrow is the whole body. Finally, even the muscles that control eye movements are no exception. They witness their own death every day, and have been in a panic of losing consciousness. The mortality rate is as high as 90% within five years from the appearance of symptoms ... I thought such diseases and people were rare, but I found them after I learned about them. Among them, there are some representatives of "frozen people", who don't forget to smile when they are in pain and send positive energy to the world. For example, Hawking: Everyone knows that this is a genius. After suffering from ALS at the age of 2 1, he was paralyzed, unable to speak, and only three fingers in his hand could move. Can gradual freezing be cured? At present, medicine is powerless. Most ALS patients can only survive for a few years after symptoms appear (the average survival time is 3-5 years), some patients can only survive for a few months, others can survive for more than 10 years, and most of them die of respiratory failure caused by respiratory muscle paralysis. Hawking's father has made such slow progress, which is very rare. In his misfortune, he may be considered lucky. Unfortunately, there is no cure for ALS at present, and doctors can treat it symptomatically. Although ALS is still an incurable disease, there are many ways to improve the quality of life of patients, so early diagnosis and treatment should be carried out to prolong the survival time as much as possible. Patients with gradual freezing are conscious vegetarians. In 20 16, with the support of the funds raised by the "Ice Bucket Challenge", the American "gradually frozen people" association in Washington issued a statement saying that these donations helped the largest-scale research on the family "gradually frozen people" and found a new gene-nek1,which is considered to be the cause of "gradually frozen people". As a rare disease, "gradually frozen people" still belongs to the blind spot of public cognition in society. So what exactly is a "frozen man"? It is called "gradual freezing" because this disease is a progressive neurodegenerative disease, which will cause the death of motor neurons in the brain, make the brain unable to control muscle movement, and muscles will shrink due to lack of exercise. At the initial stage, its symptoms include muscle weakness or stiff movements, and may also be accompanied by muscle atrophy and dysphagia. In the late stage, the patient will completely lose the ability to move. However, although patients will gradually lose their autonomy in life, their cognitive ability is often unaffected, so they are often called "conscious vegetarians". According to the statistics of the American "gradual freezing disease" association, there are about 30 thousand people suffering from this disease in the United States at present. In addition, "gradual freezing disease" has been found in all races, nationalities and societies around the world, and anyone may get sick. Among the "frozen people" patients, the most famous is the British physicist Stephen Hawking. It is said that after being infected with this disease, the expected survival time is generally 3 to 5 years, and only 5% of patients can survive for more than 20 years, and Hawking is one of these 5%. He fought against the "frozen man" for more than 40 years.