2 English reference Evodia rutaecarpa Benth. [Landau Chinese-English Dictionary]
Fructus evodiae [Landau Chinese-English Dictionary]
Evodiae [Xiangya Medical Dictionary]
Fructus [Xiangya Medical Dictionary]
Fructus Evodiae [Terminology Committee of Traditional Chinese Medicine. Terminology of Traditional Chinese Medicine (2004)]
Medicinal evodia fruit [Chinese Medicine Terminology Examination Committee. Chinese Medicine Terminology (2004)]
3 Overview of Evodia rutaecarpa
Evodia rutaecarpa is the name of traditional Chinese medicine, and it is published in Shennong Herbal Classic. Is the dried nearly ripe fruit of rutaceae Evodia rutaecarpa (Juss.) Benth., Shi Hu Evodia rutaecarpa (Juss.) Benth. var. Officialis (Dode) Huang or Evodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang [
Pharmacopoeia of the People's Republic of China (20 10 edition) records the pharmacopoeia standard of this Chinese medicine.
4 Latin name Fructus Evodiae (La) (Terminology of Traditional Chinese Medicine (2004))
5 English name medicinal evodia fruit (Terminology of Traditional Chinese Medicine (2004))
6 Evodia rutaecarpa's alias is Quyaozi, Fuchili pepper, Tea Spicy and Stinky Bubble.
Evodia rutaecarpa and tea are spicy [2].
Evodia rutaecarpa, tree chili pepper, tea spicy, gas chili pepper, bromine bubble, koji, Fu spicy, Zuo Li [3].
7. Evodia rutaecarpa(Juss.) Benth. of Rutaceae, E. rutaecarpa (Juss.) Benth. Var Officialis (Dode) Huang of Shi Hu and E. Rutaecarpa (Juss.) Benth. Var Bodinieri (Dode) Huang of Brucella [
Evodia rutaecarpa (Juss.) Benth. is a nearly ripe fruit of Evodia rutaecarpa.
8 Shrub or small tree in original plant form, 2.5 ~ 8m high. Young branches, leaf axes, petioles and inflorescences are all yellow-brown villous. Pinnate compound leaves are opposite; The lobules are 5 ~11,oblong or ovoid, 5 ~14 cm long and 2 ~ 6 cm wide, with sparse hairs on the top and white villous hairs on the bottom, with transparent glandular spots. Flowers unisexual, densely packed into terminal panicles. Bone process fruit is purplish red with thick glandular spots, and each fruit contains seeds 1 grain. The flowering period is from June to August, and the fruiting period is from September to1October.
Born in mountains, roadsides or sparse forests in warm regions.
9 Origin Evodia rutaecarpa is mainly produced in Guizhou, Guangxi, Hunan, Yunnan, Shaanxi, Zhejiang and Sichuan [2].
Evodia rutaecarpa is distributed in Guangdong, Guangxi, Guizhou, Yunnan, Sichuan, Shaanxi, Hunan, Hubei, Fujian, Zhejiang and Jiangxi.
10 harvesting and primary processing 8 ~11month when the fruit has not cracked, cut the fruit branches, dry them in the sun or at low temperature, and remove the branches, leaves and fruit stalks.
1 1 pharmacognostic fruit is pentagonal oblate with a diameter of 2 ~ 5 mm. The surface is dark yellow-green to brown, rough, a little protruding or concave oil spots. There is a five-pointed star-shaped crack at the top, and a yellow hairy fruit stalk remains at the base. Hard and brittle. The gas is fragrant and rich, and the taste is spicy and bitter.
12 The taste of Evodia rutaecarpa is pungent, bitter, hot and slightly toxic; Into the liver and stomach meridians [2].
13 efficacy and indications Evodia rutaecarpa has the effects of dispelling cold, relieving pain, lowering adverse qi, stopping vomiting, supporting yang and stopping diarrhea. Used for headache, colic, beriberi, dysmenorrhea, epigastric pain, vomiting and acid swallowing, and aphtha.
Evodia rutaecarpa has the effects of warming the middle warmer, relieving pain, reducing adverse reactions, stopping vomiting, eliminating dampness and killing insects [2].
Treat disharmony between liver and stomach, epigastric cold pain, vomiting and acid regurgitation, food retention and diarrhea, hypochondriac pain, headache due to Jue yin, hernia pain, rheumatic arthralgia, beriberi swelling and pain, dysmenorrhea and pinworm disease [2]. Decocting:1.5 ~ 4.5g [2].
Grinding vinegar and applying it to the heart of both feet (Yongquan point) to treat hypertension and oral ulcer; Made into ointment Tu Zhi eczema, yellow water sore, neurodermatitis [2].
Evodia rutaecarpa is a commonly used medicine for warming the interior in ophthalmology, which has the effects of dispelling cold, relieving pain, lowering adverse flow and stopping vomiting: it is used for treating wind-induced nebula, gray nebula, or spleen and stomach deficiency caused by deficiency of liver meridian; Obstacle of green wind caused by drinking evil, with symptoms such as swelling and pain of eyes, dizziness due to pupil distraction, dry vomiting and salivation. It is often combined with ginseng and ginger, such as Wuzhuyu Decoction.
14 chemical component Evodia rutaecarpa contains alkaloids such as Evocarpine, rutaecarpine, and hydroxyevodiamine. It also contains volatile oil, including Evodene, Evodol and limonin [2]. Seeds contain fatty acids, with evocative acid [2]. Shi Hu also contains evodiamine and Shi Hu A [2].
Evodia rutaecarpa contains evodiamine, rutaecarpine, hydroevodiamine, limonin, synephrine, evodente and so on.
15 pharmacological effects Evodia rutaecarpa has the effect of expelling gastrointestinal gas and inhibiting abnormal fermentation in the intestine [2].
The ether extract of Evodia rutaecarpa has certain inhibitory and killing effects on ascaris suum and leeches [2].
Evodia rutaecarpa decoction can inhibit staphylococcus aureus and mycobacterium tuberculosis in vitro [2].
Evodia rutaecarpa water extract has inhibitory effect on common pathogenic fungi [2]. Some components have analgesic effect [2].
Evodia rutaecarpa injection has antihypertensive effect on anesthetized rabbits, dogs and renal hypertensive dogs [2].
Evodiamine can relieve pain and raise body temperature, and can be used as diuretic and antiperspirant. Its hydrochloride can contract uterus. Sinephrine, an adrenaline substance, is also found in Evodia rutaecarpa, which can resist shock [2].
16 Evodia rutaecarpa poisoning Evodia rutaecarpa is the immature fruit of Evodia rutaecarpa, Shi Hu or Evodia pubescens [3]. Its main components are evodiamine, evodiamine, evodiamine, basilene, evolactone, evolactone alcohol and evodiamine [3]. It has the effects of warming middle warmer, dispelling cold, regulating qi and relieving pain [3].
The common dosage of this product for oral decoction is1.5 ~ 6g. [3]
16. 1 Adverse reaction mechanism Some people take 30g orally and get poisoned, which mainly damages the nervous system. [3]
16.2 clinical manifestations: The drug was poisoned for 3-6 hours, with vomiting, abdominal pain, diarrhea and fever, and in severe cases, visual impairment, illusion, hair loss, etc. There are also reports of chest tightness, headache, dizziness or rash (red-hot rash) after taking this product, and the reaction disappears after about 30min minutes. [3]
16.3 The main points of treatment for Evodia rutaecarpa poisoning are [3]:
Symptomatic treatment.
17 Pharmacopoeia Standard of Evodia rutaecarpa 17. 1 Name Evodia rutaecarpa
Wuzhuyu
EUODIAE FRUCTUS
17.2 The source of this product is rutaceae plant Euodia rutaecarpa (Juss.)Benth., Shi Hu Euodia rutaecarpa (Juss.) Benth. Var. Officialis (Dode) Huang or Evodia rutaecarpa (Juss.) Benth. Var. Bodinieri. When the fruit has not cracked in 8 ~11month, cut the fruit branches and dry them in the sun or at low temperature to remove impurities such as branches, leaves and fruit stalks.
17.3 characteristics this product is spherical or slightly pentagonal oblate with a diameter of 2 ~ 5 mm. The surface is dark yellow-green to brown, rough, with many punctate protrusions or concave oil spots. There is a five-pointed star-shaped crack at the top, and a yellow hairy fruit stalk remains at the base. The quality is hard and brittle, and the transverse section shows that the ovary has 5 cells, and each cell has pale yellow seeds 1 grain. The gas is fragrant and rich, and the taste is spicy and bitter.
17.4 Identification (1) This product is brown in powder. Non-glandular hair 2 ~ 6 cells, long140 ~ 350μ m, with obvious wall warts, and some cells contain brownish yellow to brownish red substances. 7 ~14 cells in the head of glandular hair are oval and often contain yellow-brown inclusions; Stalk 2 ~ 5 cells. There are many clusters of calcium chromate with a diameter of10 ~ 20μ m; Occasionally there is a square crystal. Stone cells are round or rectangular, with a diameter of 35 ~ 70μ m and a large cell cavity. Oil chamber fragments are sometimes visible, pale yellow.
(2) Take 0.4g of this product powder, add ethanol 10ml, stand for 30min, perform ultrasonic treatment for 30min, filter, and take the filtrate as the test solution. In addition, taking rutaecarpine reference substance and rutaecarpine reference substance, adding ethanol to make solutions containing 0.2mg 1ml and 1.5mg/ml respectively as reference substance solutions. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10 edition), absorb 2μl of each of the above three solutions, respectively spot them on the same silica gel G thin-layer plate, and use petroleum ether (60-90℃) ethyl acetate triethylamine (7: 3: 0.1) as the developing agent, unfold, take them out and air them. In the chromatogram of the test sample, fluorescent spots with the same color appear at the positions corresponding to the chromatogram of the reference sample.
17.5 inspection 17.5. 1 impurities shall not exceed 7% (appendix ⅸ a of Pharmacopoeia 7%(20 10/0).
17.5.2 The moisture content shall not exceed15.0% (the first method in appendix ⅸ h of the Pharmacopoeia of 2010 edition).
17.5.3 the total ash content shall not exceed10.0% (appendix ⅸ k of Pharmacopoeia I of 2010 edition).
17.6 the extract shall be determined according to the hot dip method under the alcohol-soluble extract determination method (appendix ⅹ a of Pharmacopoeia I, 20 10 edition), and dilute ethanol shall be used as the solvent, which shall not be less than 30.0%.
The content of 17.7 was determined by high performance liquid chromatography (appendix ⅵ d of Pharmacopoeia I of 20 10 edition).
17.7. 1 chromatographic conditions and system applicability test with octadecylsilane bonded silica gel as filler; Acetonitrile-water-tetrahydrofuran-glacial acetic acid (41:59:1:0.2) was used as the mobile phase; The detection wavelength is 225nm. Theoretical teaching should be not less than 3000 according to the peak of limonin.
17.7.2 preparation of reference solution take appropriate amounts of evodiamine reference substance, rutaecarpine reference substance and limonin reference substance, accurately weigh them, and add methanol to prepare evodiamine 0. 15mg[4] and rutaecarpine 0./kloc-0.
17.7.3 preparation of test solution take about 0.5g of this product powder (passed through the No.3 sieve), accurately weigh it, put it in a conical flask with a stopper, accurately add 25ml of 80% ethanol, weigh it, soak it 1 hour, and perform ultrasonic treatment (power 100W, frequency 40khz).
17.7.4 determination method respectively accurately suck 10μl of the reference solution and the test solution, inject them into a liquid chromatograph, and determine to obtain the product.
Calculated by dry product, the total content of evodiamine (C 19H 17N3O) and rutaecarpine (C 18H 13N30) shall not be less than 0. 15%, and limonin (C26H3008).
17.8 Evodia rutaecarpa pieces 17.8. 1 processing 17.8. 1. 1 Evodia rutaecarpa to remove impurities.
Same medicinal materials.
17.8.10.2 Make Evodia rutaecarpa. Mash Glycyrrhiza uralensis Fisch., add appropriate amount of water, decoct soup, remove residue, add clean Evodia rutaecarpa, moisten and suck it up, fry until it is slightly dry, take it out and dry it.
Every 100kg of Evodia rutaecarpa, use 6kg of licorice.
This product is shaped like Evodia rutaecarpa with a brown to dark brown surface.
17.8.1.2.1The content determination is the same as that of the medicinal materials. The total content of evodiamine (C 19H 17N3O) and rutaecarpine (C 18H 13N30) shall not be less than 0. 15%, and the content of limonin (C26H3008) shall not be less.
17.8. 1.2.2 The extract is the same as the medicinal materials.
17.8.2 Sexual taste and channel tropism: pungent, bitter and hot; There is a little poison. Liver, spleen, stomach and kidney meridians entered.
17.8.3 Function and indications: dispelling cold, relieving pain, lowering adverse flow, stopping vomiting, supporting yang and stopping diarrhea. It can be used for headache due to Jue yin, abdominal pain due to cold hernia, beriberi due to cold and dampness, abdominal pain during menstruation, abdominal T-bloating pain, vomiting and acid regurgitation, and diarrhea during night shift.
17.8.4 Usage and dosage 2 ~ 5g. Appropriate amount for external use.
17.8.5 Store in a cool and dry place.
17.9 Source