Fava bean disease is an acute hemolytic anemia that occurs in people with glucose hexosephosphate dehydrogenase (G6PD) deficiency after eating fava beans. Fava beans

(viciafaba) are also known as fava bean yellow.

Fava bean disease is found throughout southwest, south, east and north China, with Guangdong, Sichuan, Guangxi, Hunan,

Jiangxi being the most common. 70% of patients under the age of 3 years old and 90% of male patients. Adults are rare, but a few patients

do not develop the disease for the first time until middle age or old age. Because G6PD deficiency is hereditary, there is a family history of the disease in more than 40% of cases. The disease often occurs

in the early summer when fava beans are ripe. The majority of patients develop the disease after eating fresh fava beans. The onset of the disease may be late or early due to different climates in the north and south

.

A preliminary study found that the warming of fava bean extract with G6PD-deficient erythrocytes resulted in a significant decrease in reduced glutathione

(GSH) content in the erythrocytes and an increase in methemoglobin concentration. This result suggests that the fava bean leachate contains oxidizing

agent-like substances. Researchers analyzed a variety of biomasses extracted from fava beans, such as fava bean pyrimidine riboside, fava bean pyrimidine, isouracil, and poly

bars, and found that all had the effect of inhibiting G6PD activity or decreasing the GSH content of erythrocytes deficient in G6PD. It is also possible that several toxic substances act synergistically in

body. It is still not clear what the substances in fava beans that cause hemolysis are. As for why fresh

fava beans are more likely to cause disease than dried beans, studies have found more toxic substances in the skins of beans collected fresh or on cloudy days. When dried

, the serotonin and dopa in the skins are oxidized and thus less toxic.

The incidence of fava bean disease is quite complicated, such as fava bean disease occurs only in G6PD-deficient people, but not all G6 PD-deficient people

Hemolysis occurs after eating fava beans; people who have ever had a fava bean disease to eat fava beans every year, but not necessarily every year the onset of the disease; onset of the degree of hemolysis and

anemia and the amount of fava beans eaten and the amount of no parallel relationship; the incidence rate of adults was significantly lower than that of pediatrics. It can be inferred

that in addition to the lack of G6PD in erythrocytes, there must be other factors associated with the onset of the disease. It can be seen that the mechanism of hemolysis in serotonin disease

is more complex than that of drug-induced hemolytic anemia due to G6PD deficiency, and needs to be further explored.

[Treatment]: detoxification of yellow, spleen and water

Che Qian Cao 15 Tian Ji Huang 18 Talc 15 Radix Bupleurum Chinense 10 Rhizoma Pinelliae 30 Guang Mu Xiang 12 (after the next) Yun Ling 18 Rhizoma Atractylodis Macrocephalae 12 Rhizoma Atractylodis Macrocephalae

18 Radix Rehmanniae 15 Radix Angelicae Sinensis 12

[Add and subtract]:

(1) With hematuria, add Rehmanniae 15 Radix Aconiti 15

(2) For constipation, add Chuan Pu 12 Citrus aurantium 10

(3) For qi deficiency, add ginseng 10 (stewed)

(4) For nausea, add Bamboo Roots 12 Patchouli 12

(5) For hyperthermia, add Cymbopogon schoenanthus 15 Rehmannia glutinosa 20 Bamboo Leaves 12