It can be seen that the pathogenesis of angina pectoris of coronary heart disease is mainly deficiency in essence and excess in substance. Deficiency syndrome is mainly qi deficiency and yin deficiency, while excess syndrome is mainly blood stasis and qi stagnation. Therefore, the treatment of coronary heart disease should be invigorating qi and spleen, nourishing yin and tonifying kidney, promoting blood circulation and removing blood stasis. Zhengxintai Capsule and Xin Shu Ning Capsule are commonly used in clinic.
Zhengxintai Capsule consists of Radix Salviae Miltiorrhizae, Radix Puerariae, Herba Taxilli, Rhizoma Chuanxiong, Fructus Crataegi and Radix Astragali. Has the effects of invigorating qi, promoting blood circulation, removing blood stasis and dredging collaterals. It can be used for treating thoracic obstruction caused by qi deficiency and blood stasis, and the patients show chest pain, chest tightness, palpitation, shortness of breath and fatigue. Patients with coronary heart disease and angina pectoris see the above syndromes.
In the prescription, Huangqi supplements the qi of the heart, lungs and spleen, benefits the vitality, warms the triple energizer, and also expels blood stasis among the five internal organs; Pueraria lobata promotes the qi of the spleen and stomach, supplements the yin and fluid of the spleen and stomach, and the spleen and stomach are healthy, and the triple energizer is easy to remove phlegm and blood stasis; Mulberry parasitism benefits kidney qi and channels; Salvia Miltiorrhiza promotes blood circulation, Chuanxiong promotes liver blood circulation, and gives birth to hawthorn to eliminate stagnation. The three drugs have the functions of promoting blood circulation, removing blood stasis, promoting qi circulation, relieving depression and relieving pain. The compatibility of all kinds of drugs, there are tonic and dredging, tonic without stagnation of pathogenic factors, dredging without injury to the right, taking into account both the symptoms and the root causes. Tonify deficiency of five zang-organs, ascending and descending of triple energizer, benefiting qi of various zang-organs, activating blood all over the body, making qi flourishing and blood activating, and activating heart and pulse.
Modern pharmacological research shows that the drug has the functions of dilating coronary artery, resisting myocardial ischemia, resisting oxidation and protecting myocardial ischemia-reperfusion injury; It can strengthen the heart, improve cardiac output, reduce myocardial oxygen consumption and slow down heart rate; Has anoxia resistance and can improve heart function; It can obviously reduce the blood viscosity, so that the whole blood specific viscosity, plasma specific viscosity and fibrinogen concentration are obviously reduced, thus achieving the functions of reducing blood fat, inhibiting arteriosclerosis, resisting platelet aggregation, anticoagulation, thrombosis and improving the immune function of the body.
A large number of clinical practices show that Zhengxintai capsule has satisfactory curative effect on coronary heart disease and myocardial infarction, which can obviously relieve symptoms of myocardial ischemia and angina pectoris, including chest tightness, palpitation, shortness of breath, chest pain, fatigue and spontaneous sweating, improve electrocardiogram, reduce the number of ST-T changes, reduce blood lipid, blood viscosity and fibrin, and improve hemorheology. It can also improve left ventricular function and systemic symptoms, and has no effect on blood, urine, stool routine, liver and renal function of patients, and has no obvious adverse reactions and side effects.
Xin Shu Ning Tablet is composed of Ilex pubescens, Ginkgo biloba leaves, Radix Puerariae, Herba Leonuri, Herba Hedyotidis Diffusae and persimmon leaves. Has the effects of promoting blood circulation and removing blood stasis. It is used for treating chest obstruction, heartache, coronary heart disease, angina pectoris, coronary insufficiency and arteriosclerosis.
Ilex pubescens has the effects of promoting blood circulation, dredging veins, relieving swelling and pain, and clearing away heat and toxic materials, and is used for coronary heart disease, angina pectoris and vasculitis. Modern pharmacological research shows that Ilex pubescens can inhibit the influx of calcium ions in aortic smooth muscle caused by high potassium or norepinephrine, thus lowering blood pressure, lowering thromboxane A2, increasing prostacyclin and preventing the intima thickening induced by thromboxane A2, thus playing an anticoagulant role.
Ginkgo biloba leaves have the effects of promoting blood circulation, removing blood stasis, dredging collaterals, relieving pain, astringing lung, relieving asthma, resolving turbidity and reducing blood fat, and can be used for blocking collaterals due to blood stasis, chest obstruction, heartache and hyperlipidemia. Modern pharmacological research shows that Ginkgo biloba leaves have the functions of protecting the heart, improving hemorheology, resisting thrombus and lowering blood pressure. Pueraria lobata has the effects of relieving muscle stagnation, ascending yang and dredging collaterals, and can be used for chest obstruction, heartache, stroke and hemiplegia. Modern pharmacological research shows that puerarin in pueraria lobata can affect the permeability of cell membrane to sodium, potassium and calcium plasma channels and reduce myocardial excitability, thus achieving the role of preventing and treating arrhythmia.
Motherwort has the effects of promoting blood circulation, regulating menstruation, inducing diuresis and relieving swelling, and can be used for edema, oliguria, coronary heart disease, etc. Motherwort can reduce hematocrit, high (low) cut-off part of whole blood reduction specific viscosity, viscosity index and erythrocyte aggregation index, thus changing hemorheology, increasing superoxide dismutase activity, improving myocardial antioxidant capacity, stabilizing myocardial cell membrane, reducing release of myocardial enzymes, and reducing intracellular calcium overload, thereby preventing myocardial cell apoptosis, protecting myocardium and improving myocardium.
Herba Siegesbeckiae has the effects of expelling wind, dredging collaterals, promoting blood circulation and removing blood stasis, and can be used for rheumatic arthralgia, coronary heart disease, etc. Herba Siegesbeckiae has the effects of improving hemorheology, inhibiting blood coagulation and improving microcirculation. Persimmon leaves have antibacterial, anti-inflammatory, blood stasis and hemostasis effects, and are used for cardiovascular and cerebrovascular diseases, with the characteristics of removing blood stasis without damaging the body and stopping bleeding without leaving blood stasis.
It can be seen that, no matter from the perspective of traditional Chinese medicine or modern medicine, all the herbs in the prescription of Xin Shu Ning can be used for patients with cardiovascular diseases such as coronary heart disease and improve their symptoms. The combination of all kinds of drugs has the effect of promoting blood circulation, removing blood stasis and removing chest obstruction, improving patients' heart function and serological indexes, and has good clinical effect.
In a word, Zhengxintai Capsule and Xin Shu Ning Tablet, with their unique formulations, are in line with the pathogenesis of cardiovascular diseases such as coronary heart disease, and can play a role in improving symptoms and removing causes. Multi-target cleaning of blood vessels and blood can effectively protect the heart.