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What is the role of mugwort leaves ah?
1. Antibacterial effect: 1.1. mugwort leaves in vitro against Bacillus anthracis, α-hemolytic streptococcus, B-hemolytic streptococcus, diphtheria bacillus, pseudo-diphtheria bacillus, lung-like diphtherococcus, Staphylococcus aureus, Staphylococcus citriodermus, Glucococcus leucoides, Bacillus subtilis, and other 10 kinds of gram-positive aerophilic bacteria are all antimicrobial effect. Mugwort leaf oil 4 × 10 (-3) concentration (test tube method), against S. pneumoniae, Staphylococcus aureus, Staphylococcus albicans, Streptococcus aureus, Escherichia coli, Escherichia typhi, Escherichia paratyphi, dysentery bacillus fowleri, etc., with bacteriostatic effect. Wild moxa leaves, moxa sticks or moxa velvet fumigation, can be used for indoor disinfection, with Cangzhu or with calamus and andrographis or with Cangzhu, andrographis, Angelica dahurica and other mixed smoke weight, on Staphylococcus aureus, B hemolytic streptococcus, Escherichia coli, Escherichia contorta, diphtheria bacillus, typhoid fever and typhoid fever and paratyphoid fever bacillus, Pseudomonas aeruginosa, Bacillus subtilis, alkaline bacillus and Mycobacterium tuberculosis (human H37RV) have killing or inhibiting effect. Moxa smoking can also reduce bacteria on burn wounds. Guinea pig tuberculosis after moxa treatment, the disease progresses slower, lesions are lighter, especially in the later stages of the disease more obvious; in addition can enhance the phagocytic response of the reticuloendothelial cells, but the degree of enhancement is not as significant as when the animal acquires immunity; phagocytosis of the reticuloendothelial lineage cells of guinea pigs and the visceral tuberculosis lesions are consistent with the phagocytosis of the liver, the spleen by the disease when the liver and spleen damage, phagocytosis that is, the decline in the phagocytosis function. Mugwort 1.2. Smoking of Mugwort leaves has an antibacterial effect on a variety of pathogenic fungi. Water infusion and decoction of mugwort also have certain inhibitory effect on many kinds of pathogenic fungi in the test tube. 1.3. The water decoction of Ailanthus niloticus has different degrees of inhibitory effect on Staphylococcus aureus, α-hemolytic streptococcus, Diplococcus pneumoniae, diphtheria bacillus, Sonnenberg's dysentery bacillus, typhoid fever and typhoid fever bacillus, and Vibrio cholerae in the test tube. 2. Antifungal effect: Ailanthus decoction on dermatophyte fungi has the weakest inhibitory effect (compared with Huanglian, Scutellaria baicalensis and other decoctions), and in 15% concentration of Corynebacterium, began to be inhibited, 30% concentration in addition to flocculation epidermis ringworm, foot-plantar trichothecenes and Candida albicans is still developing, the other is Xulanchovia, Xulanchovia mongolica variant, dog mountain bacillus, syncytial Trichophyton rubrum, Trichophyton rubrum, rust-colored fungi. The development of Trichophyton rubrum, Trichophyton ferrugineum, and Trichophyton coriaceum was stopped. Cao Honglie et al. also proved that the water infusion of mugwort leaves (1:4), in a test tube on Trichophyton coriaceum, Xylococcus, Audubon's pemphigoid, woolly pemphigoid, red pemphigoid, asteroidal nocardia and other dermatophytes have different degrees of inhibitory effect. At the same time, Sun Xun also determined that the fumigation method of mugwort leaf has different degrees of obvious antibacterial effect on the pathogenic skin fungi such as Xulan's yellow ringworm, Xulan's yellow ringworm Mongolian variant, concentricity of Trichophyton rubrum, cordyceps rubrum, red Trichophyton rubrum, flocculent epidermidis, ferruginous small germ cell fungus, foot-plantar Trichophyton rubrum, interdigitate Trichophyton rubrum, small bud cell fungus of the dog, gypsum-like Trichophyton rubrum, Schenk's cell üsericinae, Fei's Stuffed with Materia and other pathogenic skin fungi. 3. Asthma-relieving effect: 3.1. Ailanthus oil can directly relax the smooth muscle of guinea pig trachea, and also can counteract the phenomenon of tracheal constriction caused by acetylcholine, barium chloride and histamine; and increase the flow of guinea pig lung perfusion. Ai Ye oil 0.5ml/kg gavage on acetylcholine-histamine mixture spray method of asthma guinea pigs have inhibitory effect, Ai Ye oil 2 × 10 (-4) ml/kg on guinea pigs isolated trachea has a relaxation effect, and can fight against the contraction caused by acetylcholine, barium chloride. The suspension made of mugwort leaf oil and tween-80 can inhibit the release of slow response substance (SRS-A) from lung tissue; it has the effect of direct antagonism of slow response substance and can inhibit the release of slow response substance from lung tissue and smooth muscle of trachea; after the guinea pig was gavaged with mugwort leaf oil for one time, the content of slow response substance was not reduced obviously in the lung tissue.In 1981, some people isolated two monomers from the middle-boiling-point oil of mugwort leaf which had a stronger asthma-alleviating effect. In 1981, two monomers with strong asthmatic effect were isolated from the middle-boiling-point oil of mugwort leaf, i.e., α-terpinenol and trans-vanillinol; animal experiments showed that their asthmatic effect was stronger than that of mugwort leaf oil. The terpinenol-4240-300mg/kg, α-terpinenol 80-120mg/kg by gavage, and α-terpinenol 80-120mg/kg by gavage isolated from mugwort leaf oil were able to counteract the asthma induced by histamine and acetylcholine in guinea pigs, and the other two components, trans-caryophyllene and β-caryophyllene, were shown to have an asthma-relieving effect. Inhalation of 1% α-terpinenol inhibited histamine-induced asthma in guinea pigs, and counteracted the alteration of lung mechanical function induced by sensitization and attack of ovalbumin in guinea pigs. 3.2. Wild wormwood infusion has a diastolic effect on guinea pig bronchial tubes. 4. Choleretic effect: take the capsule of mugwort leaf oil, use 2% leaf temperature to formulate the suspension (each 1ml contains 75μl of mugwort leaf oil). Rats 0.8ml/100g and 0.3ml/100g duodenal injection administration, respectively, a group of mugwort oil and two groups. Positive control group was administered with dehydrocholic acid (DHC), 0.25g per tablet in 20% suspension, 0.3ml/100g, duodenum. Carbon tetrachloride poisoning group: 1 ml/kg of carbon tetrachloride by gavage for 1 time, 24 hours of poisoning for choleretic test, and 0.3 ml/100g of ayurvedic oil for duodenal administration. The control group was administered with 2% tween 0.3ml/100g duodenum. The mice were divided into 3 groups, the mugwort oil group, 0.2ml/10g duodenal administration. Dehydrocholic acid group, 5% dehydrocholic acid 0.2ml/10g duodenal administration. Saline group, 0.2ml/10g duodenal administration. Experimental results: ayurvedic oil suspension 0.8ml/100g increased the bile flow of normal rats by 91.5%, with highly significant difference comparing with the pre-drug; 0.3ml/100g group increased the bile flow of normal rats by 89%, with highly significant difference comparing with the pre-drug; dehydrocholic acid group increased the bile flow of rats by 83.2%; bile flow of rats in carbon tetrachloride intoxication group also increased significantly! The bile flow of rats in the carbon tetrachloride intoxication group also increased significantly, and the choleretic effect was weakened and maintained for a shorter period of time than that of normal rats; 2% tween had no significant effect on the bile flow. Ai Ye oil also has obvious choleretic effect on mice, so that its bile flow increased by 26%. Inhibition of platelet aggregation: β-sitosterol and 5,7-dihydroxy-6,3',4',-trimethoxyflavonoids in mugwort leaves, they have a significant effect on the inhibition of platelet aggregation. Wen Ruixing et al. studied the concoction method of mugwort leaves. The effects of different origins of mugwort leaves and their active ingredients on platelet aggregation rate showed that different concoctions of mugwort leaves had different effects on platelet aggregation rate. The method of concoction had a great influence on the experimental results, and the experimental results of the concocted products of different methods differed greatly. Stir-fried charcoal and vinegar-stir-fried charcoal were less effective; stir-fried charcoal, vinegar-stir-fried charcoal and raw mugwort leaves had a strong inhibitory effect on platelet aggregation rate, which was extremely significant at all three dose levels (p<0.001). Among several different solvent extracts of Anguo mugwort leaves, the most prominent inhibitory effect on platelet aggregation was observed in the alcoholic extract, while the other two solvent (ethyl acetate and chloroform) extracts were also inhibitory but not as effective as the alcoholic extract.The alcoholic aqueous parts of mugwort leaves of three different origins were found to be inhibitory to platelet aggregation (p<0.001). These two doses were more effective than the other two mugwort leaves. At a dose of 136 mg/ml, the difference between the three mugwort leaves was not significant. Both components extracted from mugwort leaves, β-sitosterol and 5,7-dihydroxy-6,3',4'-trimethoxyflavone, showed highly significant inhibitory effects on platelet aggregation. However, the effect of β-sitosterol was extremely significantly superior to that of the latter at doses of 0.7 and 1.35 mg/ml (p<0.001) when compared to these two active ingredients. 6. Hemostatic effect: Ai Ye water infusion to rabbit gastric gavage to promote blood coagulation, but there are also thought that the hemostatic effect of Ai Ye has not been confirmed. Mugwort leaves are commonly used in clinical hemostatic drugs, warm menstruation hemostatic often fried charcoal, pharmacological experiments preliminary evidence: Mugwort leaves charcoal hemostatic effect is enhanced. Zhang Xuelan et al. carried out a comparative study of its hemostatic effect, as shown by the experimental results, baked products 2-5 and fried charcoal products 100% decoction can significantly shorten the coagulation and bleeding time of experimental mice, compared with the saline group, there is a significant difference between baked products 2 (180 ° C, 10 minutes), baked products 3 (180 ° C, 20 minutes) and baked products 4 (200 ° C, 10 minutes) the most significant effect on the hemostatic effect, compared with the raw group. The hemostatic effect of baked product 2 (180℃ for 10 minutes), baked product 3 (180℃ for 20 minutes) and baked product 4 (200℃ for 10 minutes) was the most obvious, and there was also a significant difference with the raw product group. The rest of the sample groups had no significant hemostatic effect. It is suggested that the charcoal production of mugwort leaves can be changed to baking method, with 18 ℃ baking 10-20 minutes and 200 ℃ baking 10 minutes, the appearance of the finished product is preferable to burnt brown. 7. Effects on gastrointestinal tract and uterus: Decoction of mugwort can excite isolated uterus of rabbits and produce tonic contraction. Crude extract also has obvious excitatory effect on isolated uterus of guinea pig. Small wild wormwood water extract has inhibitory effect on isolated rabbit intestines in large quantities. 8. On the cardiovascular system: Ono Ai water infusion on the isolated frog heart in a large number of inhibitory effect. From the Crimean Artemisia Artemisiataurica isolated Tauremizin (is a sesquiterpene lactone), isolated frog heart, cat heart and in situ cat heart can enhance its contractility, cat heart and can slow the heart rate, so that the increase in coronary blood flow, there is a simulation of the role of adrenaline. 9. Anti-allergic effect: mugwort leaf oil 0.5ml/kg gavage, guinea pig anaphylactic shock induced by ovalbumin has a counteracting effect, can reduce mortality. 10. Other effects: Ohashi Xiuji reported that mugwort leaves, mainly because of its tannin content, can make rabbits with fever due to warm prick method of body temperature drop. However, the dose of its action has been nearly lethal, so it can not be used as antipyretic. Inflammation model with mice ear coated with croton oil, volatile oil of mugwort leaves to mice subcutaneous injection or intramuscular injection of 0.0125g, have anti-inflammatory effect, the effective rate of 57.8% and 75.O%; p-value is less than 0.001. Mugwort leaves oil can also prolong the sleep time of pentobarbital sodium. Ono ai water infusion on rabbit ear vascular perfusion when a few no effect, to mice intraperitoneal or intravenous injection can reduce capillary permeability (Lochett's method). It has a significant diuretic effect in rats when administered internally, and is moderately toxic