Both with and in have the meaning of "use", but the meaning, usage and emphasis are different.

First of all, explain the differences.

1. With interpreter: prep. Use; Use; Including; along with ...

In the explanation: in the state of ...; Wearing ...; In the manner of ... ...

Second, the usage is different.

Usage 1.with: indicates how someone does something, but in different ways. When indicating the accompanying state, it means "in the same direction as", which can be followed by "noun+infinitive", "noun+present participle" and "noun+past participle".

Example:

With what? She? Used to be. She? Son? And then what? Daughter-in-law?

With her are her son and daughter-in-law.

2. Usage of in: When someone speaks or sings in a certain language or tone, he uses in.

Example:

we? Flowers? Answer? Very little? How many days? Are you online? Answer? Hotel?

We stayed in a hotel for a few days.

Third, the emphasis is different.

1. with emphasis: with means "tools, means" and so on.

Emphasis: in means to use a certain material.