The Keto diet has become increasingly popular in the last few years due to the fact that celebrities including Gwyneth Paltrow, Lebron James and Kim Kardashian have seen it as a very effective weight loss program; however, in recent years it has also started to experience some tragic states that have left many people with some questions about its effects on the human body. In recent years, some tragedies have occurred, leaving many people with questions about the ketogenic diet and how it affects the human body. Researchers at Yale University point out that please do not implement this diet plan for a long time, because, it will hurt your body.

The latest research reports that a long-term ketogenic diet will have negative effects on the body! Benefits in a week

In a study of rats, Yale researchers found that a ketogenic diet that provides 99% of calories from fat plus only 1% of calories from carbohydrates can have health benefits in the short term, but negative effects after about a week. The results provide early indications that the ketogenic diet may improve human health by reducing diabetes risk and inflammation for a limited period of time, and they represent an important first step toward the possibility of conducting clinical trials of this research in humans.

In the Yale study, published in the January 20, 2020 issue of Nature Metaboli ***, the researchers found that both the positive and negative effects of the ketogenic diet on the human body were associated with immune cells called gamma delta T cells, which are known to reduce the risk of diabetes and inflammation. This immune cell reduces the risk of diabetes and inflammation.

Lead study author Vishwa Deep Dixit, a professor of immunobiology at Yale School of Medicine, said that the ketogenic diet tricks the body into burning fat because when the amount of carbohydrates in the diet is lowered, and when the body's glucose levels are lowered as well, the body behaves as if it were starving, even though it isn't, and so the body begins to burn fat for energy. fat for the energy it needs instead of carbohydrates. In turn, this process produces chemicals called ketone bodies as an alternative fuel for energy, and as the body burns ketone bodies, tissue-protective gamma delta T cells swell throughout the body.

Both the positive and negative effects of a ketogenic diet on the body are associated with immune cells called gamma delta T cells. Ketone bodies

This is a class of compounds produced when the body is starved, fasted, or in certain pathological states (such as diabetes), and includes three compounds: acetone, acetoacetic acid, and beta-hydroxybutyric acid, although beta-hydroxybutyric acid is technically a hydroxy acid, not a ketone. When the body is in the above state, fat mobilization is enhanced, and large amounts of fatty acids are absorbed and oxidized by the liver cells; at the same time, in order to maintain a stable blood glucose concentration, it will also *** the body's gluconeogenesis. (Source: Wikipedia)

Prof. Waldemar Von Zeditz, a professor of comparative medicine, and Prof. Vishwa Deep Dixit, a professor of immunobiology, both point out that the ketogenic diet reduces the risk of diabetes and inflammation and improves the body's metabolism; rats on a one-week ketogenic diet had lower blood glucose levels and lower inflammation.

At the same time, the researchers also found that when the body is in starvation rather than actual starvation mode, fat storage occurs alongside lipolysis, said Prof. Vishwa Deep Dixit, adding that when the rats continued to eat a high-fat and low-carb ketogenic diet for more than a week, they developed diabetes and obesity when they had more fat to consume than they had fat to burn; He also states directly that this is because these rats lose the protective gamma delta T cells (Gamma delta T cells) in fat. With regard to this research argument, long-term clinical studies in humans are still needed to validate the anecdotal evidence about the health benefits of the ketogenic diet.

Comparative medicine

Comparative medicine is a unique discipline of experimental medicine that uses animal models of human and animal diseases in biomedical research; in other words, it involves and capitalizes on biological similarities and differences between species in order to better understand the mechanisms involved in disease between humans and animals. (Info source / Wikipedia)

Short-term ketogenic

In addition, Prof. Vishwa Deep Dixit said that before such ketogenic diets can be implemented or suggested to be beneficial in humans, large-scale clinical trials must be conducted under controlled conditions to understand the mechanisms underlying the metabolic and immunological benefits or potential harms in overweight and pre-diabetic individuals. With this latest discovery, researchers can now better understand how the ketogenic diet works in the human body when taken on an ongoing basis, and why the ketogenic diet can provide these health benefits to the human body for a limited period of time.

Emily Goldberg, a doctoral student in comparative medicine, said our findings highlight the interplay between metabolism and the immune system and how they coordinate and maintain functions associated with healthy tissues. Lastly, Prof. Vishwa Deep Dixit also said that diets and ideal times that are good for human health will be the subject and direction of future medical research, and if ketones can be found to be good for the human body for a short period of time, who would want to be in a state of dieting and control of the diet forever.

Source: news.yale, Nature Metaboli ***

Editorial responsibility: David