Reduced glutathione-a liver-protecting drug
indication
Used for: ① chemotherapy patients: including chemotherapy with cisplatin, cyclophosphamide, adriamycin, rubicin and bleomycin, especially in high dose chemotherapy; ② Radiotherapy patients; ③ Various hypoxemia: such as acute anemia, adult respiratory distress syndrome, septicemia, etc. ④ Liver diseases: including liver damage caused by virus, drug toxicity, alcohol toxicity and other chemical toxicity. ⑤ It can also be used for adjuvant treatment of organophosphorus, amino or nitro compound poisoning.
dosage
1.Administration route: ① intravenous injection: after dissolving it in water for injection, add it into 100ml physiological saline for intravenous drip, or add it into less than 20ml physiological saline for slow intravenous injection; ② Administration by intramuscular injection: Dissolve it in water for injection and inject it by intramuscular injection.
2. Dosage: ① Chemotherapy patients: Dissolve 1.5g/m2 in 100ml physiological saline within 15 minutes before giving chemotherapy drugs, and inject it intravenously within 15 minutes, and inject 600mg intramuscularly every day for the second to fifth days. When cyclophosphamide (CTX) is used, in order to prevent urinary system damage, it is recommended to inject this product intravenously immediately after CTX injection, and the infusion is completed within 15 minutes; When chemotherapy with cisplatin, it is suggested that the dosage of this product should not exceed 35mg/mg cisplatin, so as not to affect the chemotherapy effect. ② Liver diseases: intramuscular injection of 300mg or 600mg of this product every day. ③ Other diseases: for example, hypoxemia, the product 1.5g/m2 can be dissolved in 100ml physiological saline for intravenous infusion, and 300-600 mg intramuscular injection every day can be used to maintain the condition after the condition improves.
3. Course of treatment: Generally, 30 days is a course of treatment for liver diseases, and other conditions are determined according to the condition.
adverse effect
Even in large doses and long-term use, there are few adverse reactions. Rare sudden rash.
taboo
Those who have allergic reaction to this product are prohibited.
matters need attention
① Use this product in the hospital under the supervision of a doctor.
② It must be completely dissolved before injection, and its appearance is clear and colorless; The dissolved product can be stored for 2 hours at room temperature and 8 hours at 0 ~ 5℃.
③ Keep it out of reach of children.
Liver-protecting drugs
Liver-protecting drugs are characterized by promoting the regeneration of damaged liver cells, promoting the repair of liver cells, protecting liver cells from injury or alleviating injury. Besides reduced glutathione, other drugs related to liver protection include Tihengjian Yanggan tablets, glucose, adenosine triphosphate (ATP), coenzyme A(CoA), inosine (69 1), glucuronolactone (Gantaile), diisopropylamine dichloroacetate (Gantele), vitamin C, and compound phosphatase tablets.
In addition, there are complex nucleotide sodium, deoxynucleotide sodium, reduced glutathione (TAD), 1, 6- fructose diphosphate (FDP), D-catechin, nicotinamide, olamiphene, vitamins, And Chinese herbal preparations such as Wuji Baifeng Pill, Danggui Pill, Compound Shushe Tablet, Coriolus versicolor Gantai, Sedum Sedum, Compound Salvia Miltiorrhiza, Qiju Dihuang Pill, Melon Pedicle, Beiwuwei, Silybum marianum (Yiganling), Armillaria mellea (PseudoArmillaria mellea), Slow Liver Nourishing Capsule, Jianganle, Keli Yigan Jiedu Capsule, Leyi Yigan Capsule, Jingzhu Gantaishu Capsule, etc.
In view of the lack of specific treatment measures and drugs for viral hepatitis so far, some clinical drugs are mostly symptomatic, and the curative effect of adjuvant treatment for a certain aspect is still uncertain, and most of them need to be metabolized by the liver. Therefore, under the guidance of doctors, patients with hepatitis should carefully choose hepatoprotective drugs according to their specific conditions and avoid blind abuse.
Commonly used anti-hepatitis drugs in clinic include lamivudine, interferon, acyclovir, arabinoside, arabinoside monophosphate, ribavirin, phosphoformic acid, embedded drugs, interferon inducer (such as polycyocyte) and so on.
When the curative effect of the above drugs alone is not satisfactory, the combination of drugs can be used to enhance the curative effect. Different kinds of liver protection drugs have their own components and different side effects, so patients with liver diseases should take them under the guidance of doctors.
Pharmacological effects of liver-protecting drugs
Alcohol is easy to cause liver diseases, and many patients with liver diseases are caused by drinking, so patients should actively pay attention not to drink alcohol. Drinking a lot at a time can cause acute hepatitis outbreaks, and drinking a lot for a long time can lead to alcoholic liver diseases. Alcoholic liver diseases can be divided into mild alcoholic liver damage, alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis and alcoholic cirrhosis according to the degree.
Some liver protection drugs are often used by patients. The so-called liver protection drugs refer to drugs that can improve liver function, promote hepatocyte regeneration and enhance liver detoxification ability, such as commonly used liver protection tablets, bifendate, compound Yiganling, etc. They are actually common drugs for various liver diseases, mainly playing an auxiliary treatment role, not a fundamental treatment measure. For example, generally speaking, "liver-protecting drugs" can be subdivided into several categories, such as protecting liver and lowering jaundice, protecting liver and lowering enzymes, and protecting liver and detoxifying. Every liver disease, every hepatitis patient has its own different situation. First of all, it is necessary to find out the real situation of each patient, so as to prescribe the right medicine. For example, patients with chronic hepatitis B are in the onset stage, and transaminase and jaundice are moderately increased. At this time, drugs for protecting liver and lowering jaundice, diammonium glycyrrhizinate, potassium magnesium aspartate and Yinzhihuang injection can be used. If you are only a hepatitis B virus carrier, it is not appropriate to use these drugs. More attention should be paid to the use of powerful enzyme-lowering drugs, such as bifendate and diammonium glycyrrhizinate. Long-term drug use has certain adverse reactions, and they all have hormone-like effects. Once the drug is stopped, it may cause liver function rebound. Therefore, during the use process, it is necessary to pay attention to gradually reducing the drug withdrawal and actively treating the primary disease.
Activate immunity: activate the immune response, so that the biological antibody it has can actively devour the liver disease virus parasitic in cells and the virus in body fluids, restore liver function, and refuse to rebound.
Safe negative conversion: effectively stripping, differentiating and clearing the virus in the body, preventing liver fibrosis, improving liver function, effectively blocking the occurrence of liver cirrhosis, promoting the production of autoimmune antibodies, and achieving the purpose of comprehensive antigen serological conversion (cure).